What is SGPT?how does this affect the humanbody?does it harm if the level is 104?

You have not mentioned the unit and the technique how ever the value of 104 is high. Thalidomide as such does not cause its increase but the associated disease might cause it to increase.

Alanine aminotransferase(ALT) or SGPT

Alanine aminotransferase (ALT), formerly called serum glutamate pyruvate transaminase, or SGPT, is an enzyme necessary for energy production. It is present in a number of tissues, including the liver, heart, and skeletal muscles, but is found in the highest concentration in the liver. Because of this, it is used in conjunction with other liver enzymes to detect liver disease, especially hepatitis or cirrhosis without jaundice. Additionally, in conjunction with the aspartate aminotransferase test (AST), it helps to distinguish between heart damage and liver tissue damage.

Aspartate aminotransferase

Aspartate aminotransferase (AST), formerly called serum glutamic-oxaloacetic transaminase, or SGOT, is another enzyme necessary for energy production. It, too, may be elevated in liver and heart disease. In liver disease, the AST increase is usually less than the ALT increase. However, in liver disease caused by alcohol use, the AST increase may be two or three times greater than the ALT increase.

Normal results

Reference ranges vary from laboratory to laboratory and also depend upon the method used. However, normal values can generally be found within the following ranges, unless specified differently.

ALT: 5-35 IU/L (values for the elderly may be slightly higher, and values also may be higher in men and in African-Americans)

AST: 0-35 IU/L

Abnormal results

ALT: Values are significantly increased in cases of hepatitis, and moderately increased in cirrhosis, liver tumor, obstructive jaundice, and severe burns. Values are mildly increased in pancreatitis, heart attack, infectious mononucleosis, and shock. Most useful when compared with ALP levels.


AST: High levels may indicate liver cell damage, hepatitis, heart attack, heart failure, or gall stones.